Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool (United Kingdom) August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

  • Time-Kill Analysis for Fungi

    Time-Kill Analysis for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Time-kill curve assay is a broth-based method, and the rate of killing a fixed inoculum fungus is determined by comparing control group (no drug) and experiment group (antimicrobial agent-containing). The kill curves are constructed by plotting the C...

  • Drug Repurposing

    Drug Repurposing

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    In silico drug repositioning refers to utilize online public databases and bioinformatics tools to identify interaction networks between drugs and targets. As years of accumulation of structure information of proteins and therapeutic compounds, Creat...

  • Light/Dark Box Test

    Light/Dark Box Test

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    The LDB test is a popular animal model used in pharmacology to assay unconditioned anxiety response in rodents. The LDB apparatus has two compartments. The large light compartment (2/3 of the box) is brightly lit and open, while the small dark compar...

  • Elevated Plus Maze Test

    Elevated Plus Maze Test

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    On the test day, rats or mice are placed at the junction of the four arms of the maze, facing an open arm. They prefer to stay in the closed arms than the open arms. The number of entries into the open arms and the time spent in each arm are recorded...

  • Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Even though immunotherapy has shown great potential in improving outcomes for patients with cancer, particularly through a combination of agents targeting immune inhibitory pathways, how to optimally combine the many new immunotherapy agents being de...

  • Magic™ GLP1R Stable Cell Line

    Magic™ GLP1R Stable Cell Line

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    The glucagon-like peptide 1 receptor (GLP1R) is a member of the glucagon receptor family of G protein-coupled receptors. It is composed of two domains, one transmembrane (TMD) domain that binds the N-terminal region of GLP-1 and the extracellular (EC...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Pharmacokinetic Assays

    Pharmacokinetic Assays

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacokinetics (PK) studies are of great importance in creating new therapeutic drugs, understanding both the beneficial and harmful effects of drugs, and guiding drug development experiments and trials. In PK assays, the applied assay method shoul...

  • UGT Investigation

    UGT Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...

  • In Vitro ADME

    In Vitro ADME

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Creative Biolabs offers services in the application of in vitro experimental systems to evaluate drug absorption, distribution, metabolism, and excretion. Based on our state-of-the-art research, we seek to develop drugs by ADME studies. We are able t...

  • Drug Distribution

    Drug Distribution

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Proteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse ac...