Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Even though immunotherapy has shown great potential in improving outcomes for patients with cancer, particularly through a combination of agents targeting immune inhibitory pathways, how to optimally combine the many new immunotherapy agents being de...

  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool (United Kingdom) August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

  • Magic™ GLP1R Stable Cell Line

    Magic™ GLP1R Stable Cell Line

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    The glucagon-like peptide 1 receptor (GLP1R) is a member of the glucagon receptor family of G protein-coupled receptors. It is composed of two domains, one transmembrane (TMD) domain that binds the N-terminal region of GLP-1 and the extracellular (EC...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Pharmacokinetic Assays

    Pharmacokinetic Assays

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacokinetics (PK) studies are of great importance in creating new therapeutic drugs, understanding both the beneficial and harmful effects of drugs, and guiding drug development experiments and trials. In PK assays, the applied assay method shoul...

  • UGT Investigation

    UGT Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...

  • In Vitro ADME

    In Vitro ADME

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Creative Biolabs offers services in the application of in vitro experimental systems to evaluate drug absorption, distribution, metabolism, and excretion. Based on our state-of-the-art research, we seek to develop drugs by ADME studies. We are able t...

  • Drug Distribution

    Drug Distribution

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Proteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse ac...

  • In Vitro Pharmacodynamics

    In Vitro Pharmacodynamics

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacodynamics (PD) is the study of the biochemical, physiologic, and molecular effects of drugs on the body, and involves receptor binding, post-receptor effects, and chemical interactions. It is a study of how the drug affects the organism. It de...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...

  • Parallel Artificial Membrane Permeability Assay (PAMPA)

    Parallel Artificial Membrane Permeability Assay (PAMPA)

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Passive diffusion is an important way for drug absorption. It influences drugs pass through the intestinal epithelium, the blood brain barrier or transport across cell membranes. The PAMPA model is an artificial in vitro model suitable for the passiv...

  • Dose-Response Relationship

    Dose-Response Relationship

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Studying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...