Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • In Vitro Pharmacodynamics

    In Vitro Pharmacodynamics

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Pharmacodynamics (PD) is the study of the biochemical, physiologic, and molecular effects of drugs on the body, and involves receptor binding, post-receptor effects, and chemical interactions. It is a study of how the drug affects the organism. It de...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...

  • Dose-Response Relationship

    Dose-Response Relationship

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Studying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...

  • Rodent Behavioral Tests for Cognition

    Rodent Behavioral Tests for Cognition

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    Cognition is a psychological term that includes the processes of learning, memory, and attention, as well as perception, language, intelligence, and reasoning. Cognitive phenomena are essentially internal psychological processes which, from the exper...

  • Elevated Plus Maze Test

    Elevated Plus Maze Test

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    On the test day, rats or mice are placed at the junction of the four arms of the maze, facing an open arm. They prefer to stay in the closed arms than the open arms. The number of entries into the open arms and the time spent in each arm are recorded...

  • Magic™ GLP1R Stable Cell Line

    Magic™ GLP1R Stable Cell Line

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    The glucagon-like peptide 1 receptor (GLP1R) is a member of the glucagon receptor family of G protein-coupled receptors. It is composed of two domains, one transmembrane (TMD) domain that binds the N-terminal region of GLP-1 and the extracellular (EC...

  • Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signaling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Drugs especia...

  • Magic™ M5 Stable Cell Line

    Magic™ M5 Stable Cell Line

    Biomedical Sciences Shirley (New York) December 28, 2019 Check with publisher

    G protein-coupled receptors (GPCRs) play a crucial part in a variety of cellular physiological processes, which manifest as one popular therapeutic target for approximately 30%-40% current marketed drugs. Testing the function profiles of different co...

  • Magic™ pH-Sensitive Dye for Internalization Detection

    Magic™ pH-Sensitive Dye for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    For compounds against intracellular targets, internalization ability is one crucial characteristic, as they will rely on this process to confer their intended effects. Particularly, antibodies with internalization potencies can also act as excellent ...

  • Cassette Dosing Studies

    Cassette Dosing Studies

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Cassette dosing is an efficient technique mainly applied in drug discovery efforts of pre-clinical studies, in order to obtain pharmacokinetic data from multiple candidate drugs in a single experiment. Thus, a similar amount of information obtained f...

  • CYP Investigation

    CYP Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    A drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug i...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biological Sciences Shirley (New York) November 28, 2019 Check with publisher

    Recent antifungal drugs have many side effects which limit their clinical use. For instance, amphotericin B has severe acute and chronic toxicities, and azoles have a low susceptibility to fungal pathogens. To improve drugs' efficiency and reduce the...