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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Nanosuspension,Microemulsion

    Nanosuspension,Microemulsion

    Drug Development Shirley (New York) May 23, 2019 Check with publisher

    One of the main problems associated with poorly soluble drugs is the low bioavailability and poor solubility. Formulation as a nanosuspension is an attractive and promising alternative to address these issues. Nanosuspensions consist of poorly solubl...

  • Surfactant Solubilization

    Surfactant Solubilization

    Drug Development Shirley (New York) May 23, 2019 Check with publisher

    About 40% of drugs with market approval are poorly water-soluble and fail to reach market on account of their poor aqueous solubility. Surfactant solubilization is an effective approach to increase the solubility of poorly soluble drugs. One reason t...

  • pH Adjustment, Co-Solvent

    pH Adjustment, Co-Solvent

    Drug Development Shirley (New York) May 23, 2019 Check with publisher

    The solubilization of poorly soluble drugs is a frequently encountered challenge in screening studies of new chemical entities as well as in formulation design and development. Orally administered drugs can only be completely absorbed when they show ...

  • Protein Structure Modeling

    Protein Structure Modeling

    Cell Biology & Microbiology Shirley (New York) April 28, 2019 Check with publisher

    The three-dimensional structure of a protein provides essential information about its biological function and facilitates the design of therapeutic drugs that specifically bind to the protein target. Recent years have witnessed a tremendous increase ...

  • GPCR Screening Service

    GPCR Screening Service

    Spectroscopy Shirley (New York) April 28, 2019 Check with publisher

    Profacgen offers professional high-throughput GPCR screening service for the identification of potential GPCR-targeting drugs. G protein-coupled receptors (GPCRs) are also known as seven-transmembrane domain receptors. They are only found in eukaryot...

  • Transporter Screening Service

    Transporter Screening Service

    Immunology Shirley (New York) April 28, 2019 Check with publisher

    Transporters are a group of specialized membrane proteins that power the translocation of numerous substances, including essential nutrients, ions, neurotransmitters, cellular waste and environmental toxins, across the cellular membrane. Many transpo...

  • Hygroscopicity Testing

    Hygroscopicity Testing

    Drug Development Shirley (New York) April 1, 2019 Check with publisher

    Hygroscopicity of a material can be regarded as a physicochemical property that represents the ability of absorbing moisture from the surrounding environment. Recently, determination of the hygroscopicity is of great importance to select the most app...

  • Polymorph Screening

    Polymorph Screening

    Drug Development Shirley (New York) April 1, 2019 Check with publisher

    Given the fact that the majority of drug substances are produced by crystallization, a single chemical entity generally can adopt two or more crystalline phases, and such phenomenon can be termed as the polymorphism. Although the morphology, solvates...

  • Solubilization Improvement

    Solubilization Improvement

    Drug Development Shirley (New York) April 1, 2019 Check with publisher

    Solubility is supposed to be one of the most pivotal parameters for achieving anticipated pharmacological response which requires sufficient concentration of drug in systemic circulation. Given the unpleasant fact that the majority of drug candidates...

  • Preformulation Screening

    Preformulation Screening

    Drug Development Shirley (New York) April 1, 2019 Check with publisher

    Pre-preparation studies were initiated prior to the commencement of pharmaceutical preparation activities. In the pre-preparation stage, the physical and chemical properties of the active drug component (API) were determined. For chemical API, the kn...

  • Impurities Identification and Characterization

    Impurities Identification and Characterization

    Cell Biology & Microbiology Shirley (New York) April 1, 2019 Check with publisher

    Impurity profiling of a drug is an integral part to establish drug quality standards. According to the general guidelines stipulated by the International Conference to qualify the drug substance, the amount of acceptable level of each impurity should...

  • Purity Studies

    Purity Studies

    Bioinformatics - Data Analysis Shirley (New York) April 1, 2019 Check with publisher

    Purity studies is a method that depends on properties and chemical reaction to analyze the purity of substance, since the presence of impurities in drug substance is extremely critical issue and can have a significant impact on the quality and safety...