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DrugAge database of compounds that increase lifespan
Biomedical Sciences Liverpool August 24, 2015 Check with publisherWe're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...
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Magic™ Humanized PD-1/OX40 Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisherEven though immunotherapy has shown great potential in improving outcomes for patients with cancer, particularly through a combination of agents targeting immune inhibitory pathways, how to optimally combine the many new immunotherapy agents being de...
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Magic™ GPCR Stable Cell Lines For Antibody Function Study
Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisherG protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signaling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Drugs especia...
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Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice
Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisherMonoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...
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Magic™ pH-Sensitive Dye for Internalization Detection
Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisherFor compounds against intracellular targets, internalization ability is one crucial characteristic, as they will rely on this process to confer their intended effects. Particularly, antibodies with internalization potencies can also act as excellent ...
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de novo antibody sequencing
Molecular Biology Boston (Massachusetts) January 20, 2020 Check with publisher"Monoclonal antibody plays a key role in the development of biopharmaceuticals and diagnostic kits. The primary structure of the antibody, especially the amino acid sequence of the CDR region, is the core of antibody’s biological function. Accurate a...
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Native MS
Molecular Biology Boston (Massachusetts) January 20, 2020 Check with publisher"As continuous development of Antibody-drug conjugates (ADCs) and the improving needs for precise determination of drug structure, drug characterization technology has also been constantly updated. When the traditional mass spectrometer technology ca...
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ADCs analysis
Molecular Biology Boston (Massachusetts) January 20, 2020 Check with publisher"As continuous development of Antibody-drug conjugates (ADCs) and the improving needs for precise determination of drug structure, drug characterization technology has also been constantly updated. When the traditional mass spectrometer technology ca...
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UGT Investigation
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherDrug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...
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CYP Investigation
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherA drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug i...
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Drug Distribution
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherProteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse ac...
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Physicochemical Characterization
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherPhysicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...
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Mode of Action (MOA) Determination for Fungi
Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisherTarget deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...
