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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Antibody-Drug Conjugate

    Antibody-Drug Conjugate

    Drug Development Shirley (New York) February 11, 2019 Check with publisher

    Antibody-drug conjugates (ADCs) are an important class of highly potent biopharmaceutical drugs, which are created by coupling a small molecule anticancer drug or a therapeutic agent to an antibody that specifically targets a certain tumor marker. Th...

  • In silico Vaccine Design

    In silico Vaccine Design

    Molecular Biology Shirley (New York) January 28, 2019 Check with publisher

    Infectious diseases caused by bacteria, viruses, fungi, and parasites cause millions of deaths worldwide every year. The efficacy of all known current anti-infective agents is affected by the drug resistant form of the pathogens. Therefore, the devel...

  • Peptide Drug Bioconjugations

    Peptide Drug Bioconjugations

    Drug Development Shirley (New York) January 11, 2019 Check with publisher

    Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. The field of bioconjugation has had a considerable impact on academic research, clinical diagnostics and the productio...

  • GMP Service

    GMP Service

    Cell Biology & Microbiology Shirley (New York) January 11, 2019 Check with publisher

    Peptides have inherent properties such as high biological activity, low toxicity, and high specificity. Peptides are now increasingly used in clinical research. A number of peptide drugs are already on the market, and hundreds more are at different s...

  • Chiral Building Blocks

    Chiral Building Blocks

    Chemical Methods Shirley (New York) January 10, 2019 Check with publisher

    Building block is a term in chemistry which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the ...

  • Chiral Synthesis

    Chiral Synthesis

    Chemical Methods Shirley (New York) January 10, 2019 Check with publisher

    Chiral synthesis, is also called enantioselective synthesis, plays an essential role in the discovery of innovative drugs and materials and has been widely used in the development of pharmaceutical products and other biologically active substances. F...

  • Metabolites Synthesis

    Metabolites Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Metabolites of pharmaceutical compounds are pivotal to comprehending drug metabolism, potential drug interactions, and human drug metabolizing enzymes. Primary metabolites are synthesized by the cell because they are critical for biological growth li...

  • Intermediates Synthesis

    Intermediates Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Owing to chirality is a pivotal factor in the safety and efficacy of many drug products, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceuticals industry. It has been seen that the increasin...

  • Building Block Synthesis

    Building Block Synthesis

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    During the last decades, the synthesis of building blocks has been explored by numerous groups, which are used in pharmaceutical products and other biologically active substances. Building blocks are important intermediates for many drugs and have ma...

  • Hit to Lead

    Hit to Lead

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Hit to Lead also known as lead generation is a prerequisite for the construction of new drugs’ molecular structures and the key first step in the development of new drugs. This stage aims to obtain each hit series and try to produce more potent and s...

  • Lead Discovery

    Lead Discovery

    Bioinformatics - Data Analysis Shirley (New York) January 10, 2019 Check with publisher

    Pharmaceutical development is an extreme complex process, involves discovery of innovative active ingredients and launch of a finished product, which always take more than ten years and enormous cost. The discovery of lead compounds are the initial r...

  • Library Design

    Library Design

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    A well-designed compound library contains a broad range of truly stored chemicals and/or virtual compounds, which can meet majority requirements and truly jump-start the search for new drugs. In addition, such compound library or chemical library is ...