Project Offers - Collaborations

Premium listings
  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • Magic™ Humanized IL-17A Immune Checkpoint Knock-In Mice

    Magic™ Humanized IL-17A Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Previous studies on IL-17A has emerged its significant importance in the protective inflammation during pathogen infection and chronic inflammation related to autoimmune diseases. Accordingly, further investigation of the generation and regulation of...

  • Magic™ Humanized CD86 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD86 Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The immune system should be able to generate an appropriate inflammatory response in order to effectively eliminate tumor cells. However, the fact that most of our immune cells contain a fail-safe mechanism to ensure they are not constantly activated...

  • Magic™ Humanized IDO Immune Checkpoint Knock-In Mice

    Magic™ Humanized IDO Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Targeting checkpoint inhibitors using monoclonal antibodies results in significantly successful outcome of cancer patients compared to conventional chemotherapy. Recently, indoleamine (2,3)-dioxygenase (IDO) was identified as a novel checkpoint prote...

  • Humanized BLT Mice

    Humanized BLT Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Transplantation of human hematopoietic stem cells into severe combined immunodeficient (SCID) mice leads to long-term engraftment and systemic reconstitution with human progenitor, B, and myeloid cells, but interestedly, human T cells are rarely pres...

  • Magic™ DAG-activated GPCR Stable Cell Lines

    Magic™ DAG-activated GPCR Stable Cell Lines

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Multiple G-protein isoforms play vital roles in signal transduction, the Gq is a subtype of G-protein alpha subunits and involved in the activation of the phosphatidylinositol signaling pathway. Gq protein can activate phospholipase C (PLC) that clea...

  • Magic™ Calcium-activated GPCR Stable Cell Lines

    Magic™ Calcium-activated GPCR Stable Cell Lines

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Cell signaling networks are complicated, often composed of multiple pathways acting in concert to regulate particular cellular functions precisely. Receptors are the core components of the signaling pathway for receiving and transducing the signals. ...

  • Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signaling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Drugs especia...

  • Magic™ Humanized VEGI Immune Checkpoint Knock-In Mice

    Magic™ Humanized VEGI Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is an anti-angiogenic protein which is coded by the TNFSF15 gene. It has a carboxyl-terminal which is present on the exteri...

  • Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    ICOS (Inducible T-cell co-stimulator), also known as CD278, is a CD28-superfamily costimulatory molecule that is expressed on activated T cells as well as regulatory T cells. It is encoded by the ICOS gene. ICOS forms homodimers and plays a critical ...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Soluble cytokine receptors play pivotal roles in health and disease. Signaling of the IL-6 (cytokine interleukin-6) via its ligand, sIL-6R (soluble IL-6 receptor) is causative for the proinflammatory properties of IL-6 and appears to be an attractive...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...