Project Offers - Collaborations

Premium listings
  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Magic™ GPCR Stable Cell Lines For Antibody Function Study

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signaling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Drugs especia...

  • Magic™ Humanized VEGI Immune Checkpoint Knock-In Mice

    Magic™ Humanized VEGI Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is an anti-angiogenic protein which is coded by the TNFSF15 gene. It has a carboxyl-terminal which is present on the exteri...

  • Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Magic™ Humanized ICOS Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    ICOS (Inducible T-cell co-stimulator), also known as CD278, is a CD28-superfamily costimulatory molecule that is expressed on activated T cells as well as regulatory T cells. It is encoded by the ICOS gene. ICOS forms homodimers and plays a critical ...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Soluble cytokine receptors play pivotal roles in health and disease. Signaling of the IL-6 (cytokine interleukin-6) via its ligand, sIL-6R (soluble IL-6 receptor) is causative for the proinflammatory properties of IL-6 and appears to be an attractive...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Co-inhibitory or immune checkpoint receptors have a key function in the maintenance of immune homeostasis: their expression on effector T cells allows the proper contraction of effector T cell responses and their expression on regulatory T (Treg) cel...

  • Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Checkpoint programmed death-1 (PD-1)/programmed cell death ligands (PD-Ls) have been identified as negative immunoregulatory molecules that promote immune evasion of tumor cells. Anti-PD1 therapies show a significant improvement in response to many s...

  • Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    4-1BB (also known as TNFRSF9 and CD137) belongs to the TNF receptor family, which includes multiple T cell co-stimulatory receptors that have been targeted with agonist antibodies including GITR, CD40, CD27, HVEM, LIGHT, APRIL, and TWEAK. 4-1BB plays...

  • Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a type I transmembrane protein that expressed on activated T cells as well as other immune cells including natural killer (NK) cells, B cells, and some myeloid cells. As an inhibitory receptor, PD-1 has two known ligands,...

  • Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a costimulatory receptor that belongs to the B7/CD28 family. PD-1 is expressed on numerous immune cells such as activated T cells, natural killer (NK) cells, B cells and some myeloid cells. PD-1 regulates T-cell activatio...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...