Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The programmed cell death-ligand 1 (PD-L1), also known as B7-H1 or CD274, is commonly expressed on the surface of dendritic cells or macrophages. PD-L1 belongs to the family of immune checkpoint proteins and act as a co-inhibitory factor, which can s...

  • Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immune checkpoint-targeted therapy is producing unprecedented clinical results in various kind of cancer patients. Currently, researchers continue to identify an increasing number of immune checkpoints as novel targets for anti-tumor therapy. Co-enga...

  • Magic™ Humanized PD-L1/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Therapeutic antibodies designed to block immune checkpoint receptors or activate immune-stimulatory receptors are a potent strategy to treat cancer and function by modulating a patient's own immune system. The combination immunotherapies that associa...

  • Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immune checkpoint inhibitors that target coinhibitory T cell molecules are becoming a new pillar of cancer therapy by promoting anticancer immune responses. Nevertheless, current immune checkpoint-based therapies are effective only for a portion of c...

  • Magic™ Humanized CTLA-4/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized CTLA-4/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immunotherapy with single immune checkpoint blockade has shown remarkable rapid and durable clinical benefit for various cancer patients, providing a new method of immuno-oncology for cancer treatment. Nowadays, combining immunotherapeutic antibodies...

  • Magic™ Fluorogen Activating Protein (FAP) Assay for Internalization Assessment

    Magic™ Fluorogen Activating Protein (FAP) Assay for Internalization Assessment

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Receptor-mediated endocytosis is an endocytotic process in which specific molecules are taken into the cell when binding to surface receptors. It is highly receptor-specific, and not all surface receptors are capable of triggering ligand internalizat...

  • Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Generally speaking, there are 2 kinds of internalization formats: receptor-mediated and non-receptor-mediated. The former one is the most conventional internalization pattern. Upon binding with membrane receptors, the target molecule can translocate ...

  • Magic™ pH-Sensitive Dye for Internalization Detection

    Magic™ pH-Sensitive Dye for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    For compounds against intracellular targets, internalization ability is one crucial characteristic, as they will rely on this process to confer their intended effects. Particularly, antibodies with internalization potencies can also act as excellent ...

  • Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Generally speaking, there are 2 kinds of internalization formats: receptor-mediated and non-receptor-mediated. The former one is the most conventional internalization pattern. Upon binding with membrane receptors, the target molecule can translocate ...

  • Recombinant Human Anti-Human TGIF1 Antibody Fab Fragment, clone U24

    Recombinant Human Anti-Human TGIF1 Antibody Fab Fragment, clone U24

    Biological Sciences Shirley (New York) February 10, 2020 Check with publisher

    Recombinant Human Antibody binds selectively to Human TGIF1, expressed in E. coli. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid dependent...

  • Recombinant Human Anti-Human PAX6 Antibody, clone U53

    Recombinant Human Anti-Human PAX6 Antibody, clone U53

    Biological Sciences Shirley (New York) February 10, 2020 Check with publisher

    Recombinant Human Antibody binds selectively to Human PAX6, expressed in E. coli. his gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the de...