Project Offers - Collaborations

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • Drug-Drug Interactions

    Drug-Drug Interactions

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    As there is increasing population taking multiple medications, adverse drug-drug interactions (DDI) has become a crucial issue. If a certain component of drug A changes the activity of enzymes or transporters involved in the metabolism of drug B, it ...

  • Cardiotoxicity

    Cardiotoxicity

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-induced cardiotoxicity is the leading cause of both drug development failures and market withdraw or restriction. Compounds that exert cardiovascular toxicity, no matter acute or subtle effect, can lead to severe adverse consequences, such as ar...

  • UGT Investigation

    UGT Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...

  • CYP Investigation

    CYP Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    A drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug i...

  • Drug Distribution

    Drug Distribution

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Proteins in blood can greatly influence the drug distribution in tissues. They influence a drug distributes from blood into tissues as well as from tissues to action sites. Only drugs that are unbound to components in the blood are free to diffuse ac...

  • Drug-Drug Interactions

    Drug-Drug Interactions

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    As there is increasing population taking multiple medications, adverse drug-drug interactions (DDI) has become a crucial issue. If a certain component of drug A changes the activity of enzymes or transporters involved in the metabolism of drug B, it ...

  • Permeability and Absorption

    Permeability and Absorption

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The Caco-2 cell line is derived from a human colon carcinoma and has many characteristics that resemble intestinal epithelial cells. Caco-2 permeability assay is a good way to investigate human intestinal permeability and drug efflux. Caco-2 permeabi...

  • Pharmaceutical Stability Testing

    Pharmaceutical Stability Testing

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The purpose of these two programs is intended to identify the likely degradation products which further helps in determining the intrinsic stability of the molecule, establishing degradation pathways, and validating the stability indicating procedure...

  • Lipophilicity

    Lipophilicity

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Shake-flask procedure is a simple extraction in octanol/water system under shaking. After equilibrium between all interacting components is attained, samples are collected from both phases, and concentrations in each phase are quantified with LC-MS/M...

  • Aqueous Solubility

    Aqueous Solubility

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Solubility refers to the phenomenon that solute dissolving in a solvent to give a homogeneous system. A drug needs to dissolve in the systemic circulation and achieves desired concentration to produce a desirable pharmacological response. Low aqueous...

  • Physicochemical Characterization

    Physicochemical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Physicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...

  • Interference with Fungal Cell Membrane

    Interference with Fungal Cell Membrane

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The emerging technology of whole-genome sequencing enables exploration of therapeutic targets against pathogenic fungi to a previously unprecedented extent. However, no matter in the past or present, fungal cell membrane has always been a predominant...