Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Identification of Biomarkers by ORFeome Phage Display

    Identification of Biomarkers by ORFeome Phage Display

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    The identification of biomarkers from pathogens is a prerequisite for the development of vaccines and diagnostic assays. Creative Biolabs developed an extensive and comprehensive strategy, named ORFeome phage display, for the identification of biomar...

  • Magic™ Humanized TIGIT Immune Checkpoint Knock-In Mice

    Magic™ Humanized TIGIT Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Immune-oncology research is greatly stimulated by the clinical success of immune checkpoint modulators which lead to the identification of new tumor immunology targets. However, drug development and assessment of immune checkpoint modulators need app...

  • Other Motor Function Tests

    Other Motor Function Tests

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Creative Biolabs conducts a wide range of behavioral tests to assess motor impairments across different models of the central nervous system (CNS), including but not limited to Parkinson's disease, Huntington disease, traumatic brain injury, stroke, ...

  • Drug Dependence Liability/Withdrawal Test

    Drug Dependence Liability/Withdrawal Test

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    A key component in abuse liability testing is the appropriate evaluation of an objectively verified potential withdrawal or discontinuation syndrome induced by high dose chronic administration of the test article. Creative Biolabs conducts drug depen...

  • Marble Burying Test

    Marble Burying Test

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    A number of tests of anxiety in rodents have been developed to find out more about the biological bases of anxiety disorders and develop new, more efficient pharmacological and/or behavioral treatments. Particularly, Creative Biolabs utilizes the mar...

  • Conditioned Place Preference

    Conditioned Place Preference

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Conditioned place preference (CPP) is a procedure commonly used to assess the rewarding effects of a stimulus by measuring increased approach and contact behaviors. The popularity of this procedure in the drug abuse field attributes to several advant...

  • Light/Dark Box Test

    Light/Dark Box Test

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Creative Biolabs conducts a battery of anxiety behavioral tests to evaluate the potential therapeutic value and the anxiolytic activity of novel compounds. Specifically, the light/dark box test (LDB) is based on the innate aversion of rodents to brig...

  • Indomethacin-Induced Rodent Inflammation in Small Intestine

    Indomethacin-Induced Rodent Inflammation in Small Intestine

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Crohn's disease (CD) is a chronic condition observed in human and animal species affecting the gastrointestinal tract. It is one of the forms of Inflammatory Bowel Disease (IBD) complex, while the other being Ulcerative Colitis (UC). Animal models fo...

  • Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Immune checkpoint inhibitors have been regarded as a powerful new class of anticancer therapy. They have changed the clinical treatment method for a series of tumor types, including melanoma, non-small cell lung cancer, breast cancer, etc. Nowadays, ...

  • Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Immune checkpoint inhibitors, which target coinhibitory T cell molecules to promote anticancer immune responses, are now regarded as a novel cancer therapy of enormous potential. Nowadays, defining new targets and combination of immune checkpoint inh...

  • Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    Co-inhibitory or immune checkpoint receptors have a key function in the maintenance of immune homeostasis: their expression on effector T cells allows the proper contraction of effector T cell responses and their expression on regulatory T (Treg) cel...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) October 30, 2019 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...