Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Physicochemical Characterization

    Physicochemical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Physicochemical properties of drugs include the aspects of ionization, stability, lipophilicity, solubility, hydrogen bonding, molecular size, etc. Understanding and optimizing the physicochemical properties of compounds are the fundamental for drug ...

  • Interference with Fungal Cell Membrane

    Interference with Fungal Cell Membrane

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The emerging technology of whole-genome sequencing enables exploration of therapeutic targets against pathogenic fungi to a previously unprecedented extent. However, no matter in the past or present, fungal cell membrane has always been a predominant...

  • Interference with Fungal Protein Synthesis

    Interference with Fungal Protein Synthesis

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Fungal cell envelope (plasma membrane and cell wall) has long been taken as the primary target for developing most antifungal therapies, for their well-characterized structure, easy access, and adequate pathogenicity. However, the increasing impact o...

  • Mode of Action (MOA) Determination for Fungi

    Mode of Action (MOA) Determination for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Target deconvolution terms retrospective identification of the molecular targets that underlie the observed phenotypic responses. It is an important aspect of current drug discovery. Target deconvolution is important for elucidating the mode of actio...

  • Post Antifungal Effect (PAFE)

    Post Antifungal Effect (PAFE)

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    The post antifungal effect (PAFE) refers to growth suppression of surviving fungi following the removal of antifungals in the absence of host defense mechanisms. It is a phenomenon which is observed both in vitro and in vivo. Antifungals are capable ...

  • Time-Kill Analysis for Fungi

    Time-Kill Analysis for Fungi

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Time-kill curve assay is a broth-based method, and the rate of killing a fixed inoculum fungus is determined by comparing control group (no drug) and experiment group (antimicrobial agent-containing). The kill curves are constructed by plotting the C...

  • Dose-Response Relationship

    Dose-Response Relationship

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Studying dose response, and developing dose-response models, is vitally important for determining dosages for drugs. The dose-response relationship describes the change in effect on an organism caused by differing levels of drug doses after a certain...

  • Antimicrobial Pharmacodynamics

    Antimicrobial Pharmacodynamics

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Creative Biolabs provides both broth-based and agar-based assays for evaluating MIC. For broth-based assays, broth macrodilution and broth microdilution are provided. For agar-based assays, disk diffusion, Etest, and colorimetric assays are provided....

  • Chemical Synthesis

    Chemical Synthesis

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Creative Biolabs offers chemical synthesis service to synthesize therapeutic compounds. Our company is able to synthesize nearly all compounds you required. We are able to offer a broad range of materials used in this process, including intermediates...

  • Structure-Based Drug Design

    Structure-Based Drug Design

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Creative Biolabs provides one-step service for structure-based drug design. Our short outline of this process includes: Primarily, choose a target and evaluate the structure information. Secondary, screening different compound libraries, including ta...

  • Antibody Expression

    Antibody Expression

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Recombinant antibodies are widely used in research, diagnostics and therapeutic areas. Antibody generation has been dramatically accelerated by in vitro selection systems, particularly phage display. These new antibody generation technologies have in...

  • Molecular Engineering

    Molecular Engineering

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Structure-based drug design is the design and optimization of a hit's structure to make it more suitable for becoming a drug candidate. The structure-based design is based on a thoroughly understanding of various characters of a hit, which means how ...