Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Magic™ Humanized IL-6R Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Soluble cytokine receptors play pivotal roles in health and disease. Signaling of the IL-6 (cytokine interleukin-6) via its ligand, sIL-6R (soluble IL-6 receptor) is causative for the proinflammatory properties of IL-6 and appears to be an attractive...

  • Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/PD-L1 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The therapy of using monoclonal antibodies against inhibitory receptors on immune cells, termed immune-checkpoint blockade, for the treatment of human cancer has gained a great deal of attention among clinicians, scientists, and patients. Checkpoint ...

  • Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Co-inhibitory or immune checkpoint receptors have a key function in the maintenance of immune homeostasis: their expression on effector T cells allows the proper contraction of effector T cell responses and their expression on regulatory T (Treg) cel...

  • Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Checkpoint programmed death-1 (PD-1)/programmed cell death ligands (PD-Ls) have been identified as negative immunoregulatory molecules that promote immune evasion of tumor cells. Anti-PD1 therapies show a significant improvement in response to many s...

  • Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    4-1BB (also known as TNFRSF9 and CD137) belongs to the TNF receptor family, which includes multiple T cell co-stimulatory receptors that have been targeted with agonist antibodies including GITR, CD40, CD27, HVEM, LIGHT, APRIL, and TWEAK. 4-1BB plays...

  • Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a type I transmembrane protein that expressed on activated T cells as well as other immune cells including natural killer (NK) cells, B cells, and some myeloid cells. As an inhibitory receptor, PD-1 has two known ligands,...

  • Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a costimulatory receptor that belongs to the B7/CD28 family. PD-1 is expressed on numerous immune cells such as activated T cells, natural killer (NK) cells, B cells and some myeloid cells. PD-1 regulates T-cell activatio...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    The programmed cell death-ligand 1 (PD-L1), also known as B7-H1 or CD274, is commonly expressed on the surface of dendritic cells or macrophages. PD-L1 belongs to the family of immune checkpoint proteins and act as a co-inhibitory factor, which can s...

  • Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/TIGIT Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immune checkpoint-targeted therapy is producing unprecedented clinical results in various kind of cancer patients. Currently, researchers continue to identify an increasing number of immune checkpoints as novel targets for anti-tumor therapy. Co-enga...

  • Magic™ Humanized PD-L1/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Therapeutic antibodies designed to block immune checkpoint receptors or activate immune-stimulatory receptors are a potent strategy to treat cancer and function by modulating a patient's own immune system. The combination immunotherapies that associa...