Biomedical Sciences

Premium listings
  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

Listings
  • Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immune checkpoint inhibitors that target coinhibitory T cell molecules are becoming a new pillar of cancer therapy by promoting anticancer immune responses. Nevertheless, current immune checkpoint-based therapies are effective only for a portion of c...

  • Magic™ Humanized CTLA-4/OX40 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized CTLA-4/OX40 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Immunotherapy with single immune checkpoint blockade has shown remarkable rapid and durable clinical benefit for various cancer patients, providing a new method of immuno-oncology for cancer treatment. Nowadays, combining immunotherapeutic antibodies...

  • Magic™ Fluorogen Activating Protein (FAP) Assay for Internalization Assessment

    Magic™ Fluorogen Activating Protein (FAP) Assay for Internalization Assessment

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Receptor-mediated endocytosis is an endocytotic process in which specific molecules are taken into the cell when binding to surface receptors. It is highly receptor-specific, and not all surface receptors are capable of triggering ligand internalizat...

  • Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Generally speaking, there are 2 kinds of internalization formats: receptor-mediated and non-receptor-mediated. The former one is the most conventional internalization pattern. Upon binding with membrane receptors, the target molecule can translocate ...

  • Magic™ pH-Sensitive Dye for Internalization Detection

    Magic™ pH-Sensitive Dye for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    For compounds against intracellular targets, internalization ability is one crucial characteristic, as they will rely on this process to confer their intended effects. Particularly, antibodies with internalization potencies can also act as excellent ...

  • Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Magic™ Whole Fluorescent Cell Lines for Internalization Detection

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Generally speaking, there are 2 kinds of internalization formats: receptor-mediated and non-receptor-mediated. The former one is the most conventional internalization pattern. Upon binding with membrane receptors, the target molecule can translocate ...

  • Hepatotoxicity

    Hepatotoxicity

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Given the non-ignorable essential and the increasing attention paid to drug hepatotoxicity, fully profiling of DILI potential by predictive in vitro assays can allow optimizing of drug components during the early development stage, which enhances bot...

  • hERG Screening

    hERG Screening

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Cardiotoxicity is one of the major safety concerns in drug discovery, which is the leading reason for development termination and market withdraw or restriction. Particularly, hERG ion channel inhibition or blockade is responsible for 25-40% of all p...

  • Drug-Drug Interactions

    Drug-Drug Interactions

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    As there is increasing population taking multiple medications, adverse drug-drug interactions (DDI) has become a crucial issue. If a certain component of drug A changes the activity of enzymes or transporters involved in the metabolism of drug B, it ...

  • Cardiotoxicity

    Cardiotoxicity

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-induced cardiotoxicity is the leading cause of both drug development failures and market withdraw or restriction. Compounds that exert cardiovascular toxicity, no matter acute or subtle effect, can lead to severe adverse consequences, such as ar...

  • UGT Investigation

    UGT Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Drug-drug interaction (DDI) is a major concern when multiple drugs are co-administrated and interfere the metabolism of one another. In effort to minimize DDI liability, a comprehensive understanding of drug metabolism pathway and interference potenc...

  • CYP Investigation

    CYP Investigation

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    A drug-drug interaction occurs when two or more drugs are administrated simultaneously. Certain components of one drug may exert inducing or inhibiting effects on the metabolism of another drug by interfering the relevant enzymes, thus causing drug i...