Biological Sciences

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  • Cyclic Peptide synthesis

    Cyclic Peptide synthesis

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Cyclic peptide compounds are a class of cyclic compounds with special structure, widely biological activity and unique mechanism of action, which play an important role in natural products. Cyclic peptides are compounds of stable and uniform conforma...

  • Cyclic Peptides

    Cyclic Peptides

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Cyclic peptide compounds are a class of cyclic compounds with special structure, widely biological activity and unique mechanism of action, which play an important role in natural products. Cyclic peptides are compounds of stable and uniform conforma...

  • Post-translational Modification

    Post-translational Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Post-translational modifications (PTMs) are changes to proteins or peptides that are catalyzed by enzymes after completion of ribosomal translation and it generally have a positive impact on peptide activity. PTMs play an important role in virtually ...

  • Peptide PEGylation

    Peptide PEGylation

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    It has long been a dream in medicine and pharmacy to use peptides and proteins as drugs. The driving force for this interest is the ability of these compounds to eliminate toxic or overproduced compounds in the body and to mimic endogenous hormones, ...

  • Amino Acids Modification

    Amino Acids Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Chemical modifications of peptides introduced strategically at potential enzymatic cleavage sites may dramatically increase the in vivo stability of peptide drug candidates. One simple approach to stabilizing a peptide is to modify the side-chains of...

  • Peptide C-Terminal Modification

    Peptide C-Terminal Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    The posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20...

  • Peptide N-Terminal Modification

    Peptide N-Terminal Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Although many of the most widely recognized post-translational modifications are characteristic of secretory or cell-surface proteins, most proteins, whatever their ultimate cellular desination, undergo some modification. For proteins synthesized com...

  • Peptide Modification

    Peptide Modification

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Peptide chemists have a myriad of approaches available to optimize lead peptide structures for activity, potency and the desired selectivity for the target of interest. Thus multiple modifications and/or longer-range structural features (e.g. cycliza...

  • Epitope Mapping

    Epitope Mapping

    Biological Sciences Shirley (New York) July 18, 2019 Check with publisher

    Epitope Mapping is an essential aspect in the discovery and development of diagnostic and therapeutic antibodies. It can aid in the selection of optimized therapeutic MAbs, elucidate cancer-specific epitope markers, and define the protective (and in ...

  • Recombinant Mouse Efna3, His tagged

    Recombinant Mouse Efna3, His tagged

    Biological Sciences Shirley (New York) June 26, 2019 Check with publisher

    Cat.No.: Efna3-4055M Product Overview: Recombinant Mouse Efna3 (NP_034238.1) without the pro peptide (Met 1-Ser 205), fused with a polyhistidine tag at the C-terminus, was produced in Human Cell. Source: Human Cells Species: Mouse Tag: His Form: Lyop...

  • Recombinant Human MEP1A, His tagged

    Recombinant Human MEP1A, His tagged

    Biological Sciences Shirley (New York) June 26, 2019 Check with publisher

    Cat.No.: MEP1A-3143H Product Overview: Recombinant Human MEP1A (NP_005579.2) extracellular domain (Met 1-Gln 601), fused with a polyhistidine tag at the C-terminus, was produced in Human Cell. Source: Human Cells Species: Human Tag: His Form: Lyophil...