Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Drug Repurposing

    Drug Repurposing

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    In silico drug repositioning refers to utilize online public databases and bioinformatics tools to identify interaction networks between drugs and targets. As years of accumulation of structure information of proteins and therapeutic compounds, Creat...

  • Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-L1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Monoclonal antibodies (mAbs) are a rapidly growing class of human therapeutics representing an increasing number of drugs under development. Monoclonal antibodies have been used for treating cancer, autoimmune diseases, and infectious diseases in cli...

  • Hit Characterization

    Hit Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Creative Biolabs provides several tools to support a complete configuration of a product's higher-order structure (HOS), such as secondary and tertiary structure, aggregation and oligomerization. This service is critical to ensure the correct functio...

  • Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/CTLA-4 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a costimulatory receptor that belongs to the B7/CD28 family. PD-1 is expressed on numerous immune cells such as activated T cells, natural killer (NK) cells, B cells and some myeloid cells. PD-1 regulates T-cell activatio...

  • Cheminformatics

    Cheminformatics

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    Supported by our powerful resources, Creative Biolabs provides comprehensive cheminformatics service. We aim to analyze, simulate, model, and manipulate chemical information and use such information for better drug discovery. We use various cheminfor...

  • Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/LAG-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Programmed death-1 (PD-1) is a type I transmembrane protein that expressed on activated T cells as well as other immune cells including natural killer (NK) cells, B cells, and some myeloid cells. As an inhibitory receptor, PD-1 has two known ligands,...

  • Biophysical Characterization

    Biophysical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    DLS is one of the most popular light scattering techniques which measuring the particle size distribution even particle size down to 1 nm in diameter. Creative Biolabs provides automated DLS technology to aid your drug discovery process. This non-inv...

  • Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/4-1BB Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    4-1BB (also known as TNFRSF9 and CD137) belongs to the TNF receptor family, which includes multiple T cell co-stimulatory receptors that have been targeted with agonist antibodies including GITR, CD40, CD27, HVEM, LIGHT, APRIL, and TWEAK. 4-1BB plays...

  • Dynamic Light Scattering (DLS)

    Dynamic Light Scattering (DLS)

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    DLS is a physical technique, which is capable of determining the particle size of very small particles and polymers in solution, even at low sample concentrations. The sample is illuminated by a laser beam and the temporal fluctuations are analyzed a...

  • Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/BTLA Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Checkpoint programmed death-1 (PD-1)/programmed cell death ligands (PD-Ls) have been identified as negative immunoregulatory molecules that promote immune evasion of tumor cells. Anti-PD1 therapies show a significant improvement in response to many s...

  • Biophysical Characterization

    Biophysical Characterization

    Biomedical Sciences Shirley (New York) January 15, 2020 Check with publisher

    DLS is one of the most popular light scattering techniques which measuring the particle size distribution even particle size down to 1 nm in diameter. Creative Biolabs provides automated DLS technology to aid your drug discovery process. This non-inv...

  • Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1/TIM-3 Dual Immune Checkpoint Knock-In Mice

    Biomedical Sciences Shirley (New York) February 11, 2020 Check with publisher

    Co-inhibitory or immune checkpoint receptors have a key function in the maintenance of immune homeostasis: their expression on effector T cells allows the proper contraction of effector T cell responses and their expression on regulatory T (Treg) cel...