Mechanical Properties

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  • Published date: April 1, 2019
    • Shirley, New York, United States

For most of pharmaceutical products, solid tablet represents the most commonly used dosage form for a series of advantages: portability, small weight/size, easy to handle/ swallow, prolonged stability, and having an attractive design. A tablet is usually containing active pharmaceutical ingredient and various excipients that presented in powder, crystalline or granular form. However, the compressibility and hardness of those powders have a significant effect on the final product’s hardness, disintegration, dissolution characteristics and thickness, which are closely related to the in vivo pharmacokinetics and bioavailability. Therefore, a comprehensive study of the mechanical properties for drug substances and excipients is of great importance to guide pharmaceutical development and control the quality to meet regulations.

BOC Sciences has extensive capabilities of handling a broad range of mechanical properties testing services for various kinds of materials. By conducting a comprehensive analysis of the mechanical properties, our scientists provide our clients with the reliable analytical reports and valuable development advice for optimizing material constituents and the manufacturing process. Knowing the tablet performances can be potentially affected by many factors including the nature of API or excipients, tablet composition, tablet press speed, granulation flow, and others, our experts will fully monitor the manufacturing process to ensure those factors are controlled.

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