Enantiomer Identification (HPLC/SFC)

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  • Published date: April 1, 2019
    • Shirley, New York, United States

The analysis and identification of chiral compounds is one of the hot issues in the current analytical chemistry community. The chiral enantiomers are very similar in all aspects of their physical and chemical properties, so their separation is a difficulty in separation science. At the same time, chirality plays an extremely crucial role in the life sciences, because many of the major biological activities are achieved through strict chiral matching to generate molecular recognition. The main analytical method for chiral separation is chromatographic separation analysis.

High-performance liquid chromatography(HPLC) has a wide range of applications and strong separation capability, and it has become one of the preferred technology platforms for the separation of chiral compounds. Supercritical fluid chromatography (SFC) is a new chromatographic technique. Because it has the advantages that gas and liquid phases do not have, it can separate and analyze some objects that gas and liquid chromatography cannot solve.


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