Technologies for Chiral Analysis and Separation

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  • Published date: April 1, 2019
    • Shirley, New York, United States

Chiral compounds refer to enantiomers or diastereomers containing one or more asymmetric carbon chiral centers. In an achiral environment, the enantiomers have the same chemical properties (chemical reaction characteristics), the same physical properties (such as solubility, melting point, boiling point, entropy enthalpy, etc.) and the same chromatographic retention behavior. Therefore it is difficult to analyze under ordinary conditions. However, certain properties between enantiomers in a chiral environment show differences, which is the basis for the analysis and resolution of chiral compounds.

Early chiral analysis methods include: chiral source synthesis, crystallization splitting, chemical splitting, membrane splitting, and extraction splitting. These methods have a variety of defects. With the development of modern science and technology, especially instrumental analysis technology, scientists have focused their attention on the chromatographic separation methods of chiral compounds. Chromatography is one of the most reliable and commonly used methods for the determination of low enantiomeric impurities and is the only method that can determine the purity of enantiomers in complex matrices. At the same time, large scale preparation of enantiomers is easily achieved by chromatography. Chromatographic techniques commonly used for chiral separation include: TLC, GC, CE, SFC, and HPLC. Chromatography has become the main tool for current chiral analysis and separation.

BOC Sciences has many professional and advanced chiral analysis and separation equipment, and a large number of professional and technical personnel are responsible for tailor-made specialized chiral analysis and separation services.

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