Chiral Building Blocks

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  • Published date: January 10, 2019
    • Shirley, New York, United States

Building block is a term in chemistry which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive functional groups. As for chiral building blocks, they are valuable intermediates in the syntheses of natural products and pharmaceuticals. With the development of new drugs, it increasingly requires the use of chiral building blocks for lead optimization, and even on early stages - in search for efficient compounds. This is mainly because of the fact that at almost all the biological targets are chiral, and the drug-receptor interaction requires strict match of chirality. For example, chiral amines represent a highly attractive group of chiral building blocks for drug research and development. We can use the (R)-1-(3-cyanophenyl)ethylamine as a building block to synthesis the GABAB receptor (metabotropic transmembrane receptors for gamma-aminobutyric acid) antagonists CGP 5699A(for the treatment of Alzheimer patients), CGP 62349(PET-ligand), and related structures, as well as for radioligands.

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Alex Brown
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