Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC

  • 1.00 Dollar US$
  • Published date: November 10, 2017
    • Shirley, New York, United States

Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC is comprised of an anti-CD79B monoclonal antibody (clone ch2F2) conjugated via a SMCC linker to DM1. The DM1 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells."

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