Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC

  • 1.00 Dollar US$
  • Published date: November 10, 2017
    • Shirley, New York, United States

Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC is comprised of an anti-CD79B monoclonal antibody (clone ch2F2) conjugated via a SMCC linker to DM1. The DM1 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells."

Result 0 votes
Bella
0 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • Doxorubicin

    Doxorubicin

    Drug Development Shirley (New York) January 22, 2018 1.00 Dollar US$

    ADCs cytotoxin, Doxorubicin(Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm

  • Dolastatin 10

    Dolastatin 10

    Drug Development Shirley (New York) January 22, 2018 1.00 Dollar US$

    ADCs cytotoxin, Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm

  • Daunorubicin Hydrochloride

    Daunorubicin Hydrochloride

    Drug Development Shirley (New York) January 22, 2018 1.00 Dollar US$

    ADCs cytotoxin, Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm