Anti-CEACAM5 (clone chMAb4)-SPDB-DM4 ADC

  • 1.00 Dollar US$
  • Published date: November 23, 2017
    • Shirley, New York, United States

This ADC product is comprised of an anti-CEACAM5 monoclonal antibody (clone chMAb4) conjugated via a SPDB linker to a DM4. The DM4 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM4 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

Result 0 votes
Jerry Carter
1 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • Native™ Monkey (NHP) Anti-Membrane Protein Antibody Discovery

    Native™ Monkey (NHP) Anti-Membrane Protein Antibody Discovery

    Drug Development Shirley (New York) July 3, 2020 1.00 Dollar US$

    Creative Biolabs now provides exclusive Native™ monkey antibody discovery service to worldwide customers. https://www.creative-biolabs.com/native-monkey-nhp-anti-membrane-protein-antibody-discovery.html

  • Native™ Horse Anti-Membrane Protein Antibody Discovery

    Native™ Horse Anti-Membrane Protein Antibody Discovery

    Drug Development Shirley (New York) July 3, 2020 1.00 Dollar US$

    Creative Biolabs now provides exclusive Native™ horse antibody discovery service to worldwide customers. https://www.creative-biolabs.com/native-horse-anti-membrane-protein-antibody-discovery.html

  • Native™ Hamster Anti-Membrane Protein Antibody Discovery

    Native™ Hamster Anti-Membrane Protein Antibody Discovery

    Drug Development Shirley (New York) July 3, 2020 1.00 Dollar US$

    Creative Biolabs now provides exclusive Native™ hamster antibody discovery service to worldwide customers. https://www.creative-biolabs.com/native-hamster-anti-membrane-protein-antibody-discovery.html