Anti-DLL3 (clone SC16.15)-PBD dimers ADC

  • 1.00 Dollar US$
  • Published date: November 29, 2017
    • Shirley, New York, United States

This ADC product is comprised of an anti-DLL3 monoclonal antibody (clone SC16.15) conjugated via a linker to PBD dimers. The PBD dimers is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PBD dimers binds to DNA, causes DNA damage. Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

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Bella
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