Anti-ErbB2 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1

  • 1.00 Dollar US$
  • Published date: March 6, 2018
    • Shirley, New York, United States

https://www.creative-biolabs.com/car-t/pcdcar1-erbb2-h-28oxζ-t-276.htm The vector of anti-ErbB2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human ErbB2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-ErbB2 antibody linked to a CD28 transmembrane domain/ endodomain and OX40, CD3-zeta signaling domains. And the vector product was designed as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.

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