Anti-FLAG-SPDP-NCS ADC

  • 1.00 Dollar US$
  • Published date: December 15, 2017
    • Shirley, New York

https://www.creative-biolabs.com/adc/target-flag-44.htm This ADC product is comprised of an anti-FLAG monoclonal antibody conjugated via a SPDP linker to NCS. The NCS is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released. Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.

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