Anti-FN1 (clone F8)-DM1-SH ADC

  • 1.00 Dollar US$
  • Published date: December 15, 2017
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-fn1-45.htm This ADC product is comprised of an anti-FN1 monoclonal antibody (clone F8) conjugated via a linker to DM1-SH. The DM1-SH is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1-SH binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

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