Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC

  • 1.00 Dollar US$
  • Published date: December 18, 2017
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-fut3-48.htm This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone hu3S193) conjugated via a AcBut linker to CalichDMH. The CalichDMH is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, CalichDMH binds to DNA, causes DNA damage. Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released. Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

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