Anti-FXYD5 (clone M53)-PEG-cardiac glycoside ADC

  • 1.00 Dollar US$
  • Published date: December 18, 2017
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-fxyd5-49.htm This ADC product is comprised of an anti-FXYD5 monoclonal antibody (clone M53) conjugated via a PEG linker to cardiac glycoside. Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation. Cardiac glycosides are organic compounds containing a glycoside (sugar) that act on the contractile force of the cardiac muscle. Because of their potency in disrupting the function of the heart, most are extremely toxic. These glycosides are found as secondary metabolites in several plants, and in some insects, such as the milkweed butterflies, that consume the plants. Chemically, the aglycone [non-sugar] part of cardiac glycoside is a steroidal moiety.

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