Anti-HER2-MODO ADC

  • 1.00 Dollar US$
  • Published date: November 30, 2017
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-erbb2-37.htm This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a linker to MODO. The MODO is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MODO binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. Dolastatin is originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers.

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