Anti-IL2RA-PBD ADC

  • 1.00 Dollar US$
  • Published date: December 18, 2017
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-il2ra-58.htm This ADC product is comprised of an anti-IL2RA monoclonal antibody conjugated via a linker to PDB. The PDB is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, PDB binds to DNA, causes DNA damage. Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

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