Anti-TPBG (clone A1)-AcBut-calicheamicin ADC

  • 1.00 Dollar US$
  • Published date: January 18, 2018
    • Shirley, New York, United States

https://www.creative-biolabs.com/adc/target-tpbg-100.htm This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via an AcBut linker to calicheamicin. The calicheamicin is targeted to TPBG-positive cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, calicheamicin binds to DNA, causes DNA damage, and subsequently, induces cell death. Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released. "Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
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