Anti-TPBG (clone A1)-SMCC-DMA ADC

  • 1.00 Dollar US$
  • Published date: January 18, 2018
  • Modified date: January 18, 2018
    • Shirley, New York, United States

http://science-marketplace.org/services/drug-development_1/anti-tpbg-clone-a1-smcc-dma-adc_i3004
This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via a SMCC linker to DMA. The DMA is targeted to TPBG-positive cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

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