Antibody-Drug Conjugate

  • Check with publisher
  • Published date: February 11, 2019
    • Shirley, New York, United States

Antibody-drug conjugates (ADCs) are an important class of highly potent biopharmaceutical drugs, which are created by coupling a small molecule anticancer drug or a therapeutic agent to an antibody that specifically targets a certain tumor marker. Through combining the targeting capabilities of monoclonal antibodies with the cancer-killing ability of cytotoxic drugs, ADCs are able to distinguish between healthy and diseased tissue. Therefore, ADCs are intended to target and kill only the cancer cells but not healthy cells compared with traditional chemotherapy drugs. ADCs have been designed as a targeted therapy for the treatment of cancer and have drawn wide attention among the public.

For ADCs, antibodies targeting a specific antigen are only found on target cells. Once it binds to the cell, it triggers internalization of the antibody, together with the drug. This delivers drugs with a very high specificity to the diseased cells, in turn, leading to cell death. It maximizes the efficacy and minimizes systemic exposure to the associated risk of side effects.

Result 0 votes
Alex Brown
0 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • MED4 Peptide

    MED4 Peptide

    Drug Development Shirley (New York) January 22, 2019 Check with publisher

    This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple iso...

  • LZTR1 Peptide

    LZTR1 Peptide

    Drug Development Shirley (New York) January 22, 2019 Check with publisher

    This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localiz...

  • Peptide Drug Bioconjugations

    Peptide Drug Bioconjugations

    Drug Development Shirley (New York) January 11, 2019 Check with publisher

    Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. The field of bioconjugation has had a considerable impact on academic research, clinical diagnostics and the productio...