Solubilization Improvement

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  • Published date: April 1, 2019
    • Shirley, New York, United States

Solubility is supposed to be one of the most pivotal parameters for achieving anticipated pharmacological response which requires sufficient concentration of drug in systemic circulation. Given the unpleasant fact that the majority of drug candidates (more than 75% of the total compounds being tested) are practically insoluble in water, the low aqueous solubility hence represents a major challenge for scientists to develop the formulation for many of chemical entities. Since low aqueous solubility of a compound often implies an undesirable bioavailability and finally severely limits its commercial viability, achieving desired solubility is, therefore, becoming increasingly prevalent in drug pipelines across the industry.

At BOC Sciences, various techniques such as physical and chemical modifications of drug, particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation and other methods will be applied to improve the solubility of your hydrophobic drugs. Our experts have extensive expertise in approaching many kind of drug substance solubility challenges especially the BCS II chemical entities. More importantly, the solubility enhancement technologies and methods will be identified and selected depends on drug property, site of absorption, and required dosage form characteristics, which helps eliminate rework and worry later on, saving you time and money.

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Alex Brown
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