Tri-Methyl Histone H3-K27 Quantification Kit (Colorimetric)

  • Check with publisher
  • Published date: June 6, 2017
  • Modified date: July 23, 2018
    • United States

Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. G9a and polycomb group enzymes such as EZH2 are histone methyltransferases that catalyze methylation of histone H3 at lysine 27 (H3-K27) in mammalian cells. Tri-methylation of H3-K27 is a facultative heterochromatin mark which promotes the recruitment of polycomb group proteins for gene silencing. Increased H3-K27 tri-methylation is found to be involved in some pathological processes such as cancer progression. The H3-K27 tri-methylation can be also changed by inhibition or activation of HMTs. Thus quantitative detection of tri-methyl histone H3- K27 would provide useful information for better understanding epigenetic regulation of gene activation/repression and for developing HMT-targeted drugs. The Tri-Methyl Histone H3-K27 Quantification Kit (Colorimetric) provides a tool for measuring tri-methylation of histone H3-K27.

Result 0 votes
Linna Green
0 votes

Useful information

  • Avoid scams by acting locally or paying with PayPal
  • Never pay with Western Union, Moneygram or other anonymous payment services
  • Don't buy or sell outside of your country. Don't accept cashier cheques from outside your country
  • This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"

Related listings

  • CYP3A5 Green Screening Kit

    CYP3A5 Green Screening Kit

    Drug Development (United States ) June 6, 2017 Check with publisher

    CYP450 Screening Kits are high-throughput fluorescence-based assays for detection of enzyme-drug interactions and CYP450 inhibition. They provide an optimized method for studying isozyme-specific CYP450-drug interactions, metabolism, and inhibition. ...

  • Triose Phosphate Isomerase Activity Colorimetric Assay Kit

    Triose Phosphate Isomerase Activity Colorimetric Assay Kit

    Drug Development (United States ) June 6, 2017 Check with publisher

    Triose Phosphate Isomerase (TPI or TIM: EC is an important enzyme for glycolysis. It reversibly interconverts dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, thus maintaining the equilibrium of these two triose phosphates. TPI con...

  • TORC2 Nuclear Translocation Assay Kit

    TORC2 Nuclear Translocation Assay Kit

    Drug Development (United States ) June 6, 2017 Check with publisher

    Nuclear Translocation cells are engineered to co-two fusion proteins: a) Enzyme Donor (ED) tagged target protein; b) an Enzyme Acceptor (EA) tagged TAZ domain, derived from the CBP/P300 transcription factor, that localizes to the nucleus. Depending o...