Anti-38C13 Id Antibody-Cytokine Fusion Protein, IgG (chS5A8)-IL2

  • 1.00 Dollar US$
  • Published date: June 29, 2020
    • Shirley, New York, United States

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-38C13 Id IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the 38C13 Id as well as the biological activity of IL2. Anti-Id IgG1-mouse IL2 fusion protein (chS5A8-IL2) was more effective in the in vivo eradication of the 38C13 tumor than the combination of the anti-Id Ab and IL2 or irrelevant Ab-IL2 fusion protein. This immunocytokine was a useful tool for the study of the mechanisms of protective immunity to B cell lymphoma and for the evaluation of different therapeutic approaches based on the stimulation or suppression of the immune response. https://www.creativebiolabs.net/Anti-38C13-Id-Immunocytokine-IgG-chS5A8-IL2-22491.htm

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Jerry Carter
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