Anti-38C13 Id Antibody-Cytokine Fusion Protein, scFv (chS5A8)-IL2

  • 1.00 Dollar US$
  • Published date: June 29, 2020
    • Shirley, New York, United States

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-38C13 Id scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the 38C13 Id as well as the biological activity of IL2. scFvS5A8-(IL2) had a short life and was eliminated 20-fold faster than chS5A8-(IL2), failed to confer protection suggesting the relevance of the Fc effector functions such as ADCC in anti-tumor activity against 38C13. This immunocytokine was a useful tool for the study of the mechanisms of protective immunity to B cell lymphoma and for the evaluation of different therapeutic approaches based on the stimulation or suppression of the immune response. https://www.creativebiolabs.net/Anti-38C13-Id-Immunocytokine-scFv-chS5A8-IL2-22492.htm

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Jerry Carter
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