Polysialic Acid Vaccines

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  • Published date: November 30, 2018
    • Shirley, New York, United States

Creative Biolabs is a world leader in the field of cancer vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for polysialic acid based cancer vaccines. We guarantee the finest results for our customers all over the world.

Polysialic Acid (PSA) is an oncofetal antigen. The “embryonic” form of neural cell adhesion molecule (N-CAM) is expressed on the cell surface of a number of important tumors such as on Wilms’ tumor, small cell lung cancer, neuroblastomas, and rhabdomyosarcoma. Several monoclonal antibodies, including mAb 735 and NP-4, recognize these long polysialic acid chains and have allowed characterization of this potential antigen in both normal and malignant tissue. Also, because of the established influence of PSA on cell migration, it has been closely associated with tumor metastasis.

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Jerry Carter
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