Tri-Methyl Histone H4K20 Quantification Kit (Fluorometric)

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  • Published date: June 6, 2017
  • Modified date: July 23, 2018
    • United States

Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for Epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcriptional repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. PR-SET7, SET9, SUV4.20h, and ASH1are histone methyltransferases that catalyze methylation of histone H4 at lysine 20 (H4K20) in mammalian cells. Tri-methylation of H4K20 acts as a passive feature or structure determinant for chromatin degradation and release, as well as being an Epigenetic marker of early apoptosis. Tri-methylation of H4K20 is also considered as a common hallmark of human cancer. The H4K20 tri-methylation can be changed by inhibition or activation of HMTs. Therefore, quantitative detection of tri-methyl histone H4K20 would pro-vide useful information for better understanding Epigenetic regulation of tumori-genesis and apoptosis, as well as for developing HMT-targeted drugs. Tri-Methyl Histone H4K20 Quantification Kit (Colorimetric) provides a tool for measuring tri-methylation of histone H4K20.

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