de novo antibody sequencing

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  • Published date: January 20, 2020
    • Boston, Massachusetts, United States

"Monoclonal antibody plays a key role in the development of biopharmaceuticals and diagnostic kits. The primary structure of the antibody, especially the amino acid sequence of the CDR region, is the core of antibody’s biological function. Accurate and rapid analysis of its complete sequence is of great importance for characterization of antibody products. Analysis of the primary antibody sequence is the basis for antibody development and humanization for developing antibody-based drugs. However, due to the variation and modification of antibody products, the sequence information of most antibodies is often not included in the available databases. De novo sequencing technology uses advanced data processing algorithm for sequence analysis, has a superior advantage versus database dependent traditional methods. Antibody sequence can be accurately analyzed using the de novo sequencing method, with no need for database searching.

Based on the world's most advanced mass spectrometry instrument, Obitrap Fusion Lumos, and combined with rich experience in bioinformatics analysis, MtoZ Biolabs has established a new generation of antibody de novo sequencing platform to achieve accurate analysis of the primary antibody structure. This platform is suitable for sequence analysis of different subtype antibodies, such as IgG and IgM, and different types of antibodies, including fluorescently conjugated antibodies, immobilized antibodies, and antibodies from different species. "

http://www.mtoz-biolabs.com/antibody-de-novo-sequencing.html

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