Enzymatic Crosslinking Services

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  • Published date: February 26, 2019
  • Modified date: October 17, 2019
    • Shirley, New York, United States

Although small molecule-based crosslinkers are economic and efficient for conjugation chemistry, they may not be the best fit for some applications such as food manufacturing and pharmaceutical production, where residual organic compounds cannot be tolerated and may lead to safety incidents. Such concerns, however, can be largely addressed by our selection of enzyme-based crosslinking strategies1 as they inherently have high substrate specificity. Enzymes, as their structural integrity and function is best preserved under physiological conditions, are expected to be more favorable in crosslinking proteins than chemical approaches that often require unusual pH conditions or the use of organic solvent. Therefore, enzymatic crosslinking strategies not only provide site-specific reaction but also deliver maximized preservation of the structural integrity of proteins.

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Anna Camp
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