Fusion protein expression

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  • Published date: May 30, 2019
  • Modified date: October 17, 2019
    • Shirley, New York, United States

Fusion proteins are widely used to investigate protein functions, and to facilitate protein expression and purification, as well as to promote protein bio-availabilities. In the field of biological medicine, in particular, fusion proteins play important roles in achieving prolongation in vivo and direct targeting of drug candidates.

Currently, one of the most promising fusion proteins is the Human serum Albumin (HSA) fused therapeutic protein. In the last few decades, HA has been found as a drug delivery vector for tumor treatment, as albumin can accumulate in solid tumor. Because of this reason, gene fusion protein with albumin has attracted increasing attention in the pharmaceutical industry. HA-GLP1 fused protein (Tanzeum), for treatment of type 2 diabetes, was approved by FDA in 2014. HA-IX clotting factor fused protein (IDELVION), for treatment of hemophilia, was approved by FDA in 2016. By far, more than 60 therapeutic recombinant HA-fusion proteins have been successfully expressed; and some of them have entered medicinal stage.

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Anna Camp
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