Hydrophobic Tag Services

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  • Published date: March 29, 2019
  • Modified date: October 17, 2019
    • Shirley, New York, United States

Despite the great progress in developing ligands to specific proteins, there are only about 300 molecular targets for approved drugs have been characterized. This indicates that a large fraction of the proteome can be considered “undruggable” by current technologies. Thus, finding therapeutic agents to treat disease-causing targets that are now thought to be undruggable will largely expand the boundary of the pharmaceutical arsenal. A remaining challenge in small-molecule discovery is to determine whether the failure of a small-molecule inhibitor is due to unpredicted in vivo metabolism or whether it is simply due to the poorly selected target. This question can be answered, at least in part, by in vivo validation of the drug target, which generally requires a known inhibitor of the protein. Recently, a new technology termed “Hydrophobic Tag” has been discovered to enable small-molecule control over the target protein in the absence of a direct ligand, providing an ideal way to study and validate potential drug targets in various disease models.1
https://www.profacgen.com/hydrophobic-tag-services.htm

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