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  • Published date: December 27, 2019
    • Shirley, New York, United States

Thioredoxin reductases (TR, TrxR) (EC are the only known enzymes to reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group, a NADPH binding domain, and an active site containing a redox-active disulfide bond.

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Thomas Schmitt
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