Syntheses of Novel Derivatives of NMDARs Allosteric Modulators

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  • Published date: April 14, 2019
    • Ukraine

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels wich is activated by L-glutamate (the brain’s primary excitatory neurotransmitter). They have many critical roles in CNS function and in various neurological and psychiatric disorders.
Otava offers the chemical optimization service - syntheses of NMDARs targeted-specific sets of novel sulfonamides, quinazoline-4-ones, pyrazolines, iminothiazolidinones, N-arylbenzamides, coumarin-3-carboxylic acids, benzenesulfonamides, thiazoles and tetrahydroisoquinolines for your biological projects. These novel compounds will be selected from a sets of 1,000 - 2,000+ unique virtual derivatives for each chemical class using our company’s proprietary molecular modeling platform.
These target-specific sets of novel derivatives will be synthesized exclusively upon your request.
Novel derivatives of NAMs and PAMs provide a perfect basis for drug discovery projects related with pain, stroke, epilepsy, schizophrenia, post-traumatic stress disorder, depression and various neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

To get the qualified quotation for the lead optimization please fill the contact form or contact us directly
http://www.otavachemicals.com/services/chemical-optimization/421-syntheses-of-allosteric-modulators-of-nmdars

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Nadiia Kachaput
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