Synthesis of Arylpiperazines as Perspective Toxoplasma gondii Dihydrofolate Reductase Inhibitors

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  • Published date: July 5, 2019
    • Kyiv, Kyivska, Ukraine

Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Approximately one-third of the population worldwide is chronically infected with T. gondii. First-line treatment of toxoplasmosis is a therapy based on dihydrofolate reductase (DHFR, DHFRP1, DYR) inhibitors which act on the folate metabolic pathway, thereby inhibiting T. gondii proliferation and survival.

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Design and synthesis of novel arylpiperazines is a promising direction in toxoplasmosis treatment.

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Nadiia Kachaput
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