Cell-free Membrane Protein Expression

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  • Published date: June 15, 2016
  • Modified date: July 13, 2017
    • United States

Creative Biolabs provides unmatched membrane protein expression service.

Membrane proteins occupy one fourth of total encoding genes in genome. They localize on the cell membrane, play various roles such as signal transduction, transportation and ligand-binding. It is estimated more than half of the drug candidates target membrane proteins, mainly G-protein coupled receptors (GPCRs) and ion channels. However, due to the nature of membrane protein, traditional protein expression methods encounter obstacles such as low amount of expression, inadequate post-translational modification, misfolding, and loss of bio-activity.
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