Biology & Physiology

Listings
  • Magic™ Humanized PD-1 Immune Checkpoint Knock-In Mice

    Magic™ Humanized PD-1 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Management of cancer is a big problem, not only because the difficulties in developing new drugs but also because tumor cells usually acquire resistance to anti-cancer drugs to avoid immune destruction (immune escape). One of the most important mecha...

  • Magic™ Humanized LAG3 Immune Checkpoint Knock-In Mice

    Magic™ Humanized LAG3 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Recent achievements in cancer immunotherapy especially immune checkpoint modulators are reshaping the way of conventional cancer treatment. Nowadays, the rapid development of immune checkpoint targeting drugs has become one of the hotspots that are a...

  • Magic™ Humanized OX40 Immune Checkpoint Knock-In Mice

    Magic™ Humanized OX40 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Administration of anti-OX40 increases proliferation of peripheral blood CD4+ and CD8+ T cells, increases responses to recall and naïve reporter Ags, and increases endogenous tumor-specific immune responses. Several agonistic anti-OX40 antibodies are ...

  • Magic™ Humanized CD27 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD27 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    The activity of CD27 is restricted by the transient availability of its ligand CD70/TNFSF7, which is constitutively expressed on medullary thymic epithelial cells (mTECs) and dendritic cells. Apart from this, CD70/TNFSF7 is specifically expressed aft...

  • Magic™ Humanized SIRPα Immune Checkpoint Knock-In Mice

    Magic™ Humanized SIRPα Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    In a wide variety of preclinical models, therapies that block the CD47/SIRPα axis stimulate phagocytosis of cancer cells in vitro and anti-tumor immune responses in vivo. Nowadays, many therapeutics targeting the CD47/SIRPα axis are under preclinical...

  • Magic™ Humanized CD28 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD28 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    CD28 and CTLA4 are highly homologous and compete for the same ligands [B7-1 (CD80) and B7-2 (CD86)]. The affinity of CTLA4 binding to these ligands is higher than CD28, which enables CTLA4 to compete with CD28 for ligands and suppress effector T cell...

  • Magic™ Humanized CD137 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD137 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    CD137 is one of the tumor necrosis factor (TNF) receptor family member, which is also known as TNFRSF9 and 4-1BB. CD137 is expressed on activated T cells, while to a larger extent on CD8+ than on CD4+ T cells. Additionally, CD137 is also found on den...

  • Impurity Characterization and Management

    Impurity Characterization and Management

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Creative Biolabs has the experience of using analytical techniques to characterize impurities or contaminants and pays attention to the impurities that are called Potential Genotoxic Impurities (PGIs), which are known to be potential mutagens or carc...

  • Magic™ Humanized GITR Immune Checkpoint Knock-In Mice

    Magic™ Humanized GITR Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Glucocorticoid-induced TNFR-related protein (GITR) or activation-inducible TNFR family receptor (AITR), which is also known as a member of the tumor necrosis factor receptor superfamily (member 18 as TNFRSF18), is currently of great interest to resea...

  • DNA Microinjection

    DNA Microinjection

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Microinjection is a useful technique that plays an important part in the generation of genetically modified mouse and rat models. Different microinjection systems can exist, the construction and configuration of which directly depends on the type of ...

  • Magic™ Humanized TNF-α Immune Checkpoint Knock-In Mice

    Magic™ Humanized TNF-α Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable responses in patients with melanoma and other solid tumors. Tumor necrosis factor (TNF or TNF-α) is a major pro-inflammatory cytokine involved in early The primary c...

  • Magic™ Humanized CD276 Immune Checkpoint Knock-In Mice

    Magic™ Humanized CD276 Immune Checkpoint Knock-In Mice

    Biology & Physiology Shirley (New York) September 30, 2019 Check with publisher

    Immune checkpoints refer to proteins that act as T cell receptor (TCR) co-signaling partners which deliver either positive or negative signals to T lymphocytes. Blocking the actions of the immune checkpoint receptors can produce a potent anti-tumor r...