Biomedical Sciences

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  • DrugAge database of compounds that increase lifespan

    DrugAge database of compounds that increase lifespan

    Biomedical Sciences Liverpool August 24, 2015 Check with publisher

    We're starting a new database of drugs and compounds (including natural products) with anti-ageing properties that extend longevity in model organisms. The database will be called DrugAge, and although we have some data already, we are looking for da...

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  • Analysis/Purification

    Analysis/Purification

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Impurities and the unwanted by-products, especially the potentially toxic compounds, should be strictly controlled below a certain level set by the regulatory agencies. That’s mainly ascribed to the fact that these pharmaceutical impurities such as r...

  • technology transfer

    technology transfer

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    In the past, technology transfer (tech transfer) mainly referred to standard transfer or technology instruction from technology department to production department within the same company. Now tech transfer is the process by which an original innovat...

  • Scale-up

    Scale-up

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    "Scaling-up" refers to increasing the scale of a product, device, process or technology that operate at a smaller scale. Much time has been spent, large scale production plant has been established based on laboratory data, however, it turns out that ...

  • Reaction Condition Optimization

    Reaction Condition Optimization

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    As new drugs continue to be marketed, strategies to improve drug development and manufacturing processes become critical. In the development of pharmaceutical and chemical products, it is becoming more and more important to improve the yield, reduce ...

  • Route Scouting and Development

    Route Scouting and Development

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Route scouting refers to discussion and investigation of completely different routes to the target molecules. Recently, route scouting for preclinical and clinical development has emerged as an important area of interest. The impact of good route sel...

  • Process R&D

    Process R&D

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    About 30 years ago, “Process R&D” in the pharmaceutical market only refers to make a chemical process scalable. With the growing awareness of the need to change and develop more efficient processes in pharma industry, a new chemistry filed “Proce...

  • Azidation

    Azidation

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Organic azide compounds contain azide-based high-energy reactive functional groups and are an important class of organic synthesis intermediates and target compounds, which are widely used in organic synthesis, chemical biology, functional materials,...

  • Diazotization

    Diazotization

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Diazotization is the reaction of primary amine and nitrite at low temperature to produce diazonium salt. The reaction of aromatic amine and nitrite to produce diazonium is diazotized. Aromatic amine is often used as a heavy nitrogen component and nit...

  • Nitrosation

    Nitrosation

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Nitrosation is the reaction introducing nitroso (-NO) to the carbon or nitrogen atoms of organic molecules. The commonly used reagents for nitrosation are nitrous acid (nitrite plus acid) and nitrite. Compared with nitro compounds, nitroso groups pos...

  • Phosphorylation

    Phosphorylation

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Phosphorylation is a chemical process that usually refers to the esterification reaction between hydroxy compounds (such as fatty alcohols, alkyl phenols, lipids, etc.) and phosphorylation reagents. The developed phosphate esters can be classified as...

  • Cyanation

    Cyanation

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Cyanation is a reaction in which a cyano group is attached or substituted on various substrates. Cyano groups is a strong electron-withdrawing group and many cyanides are widely used in organic synthesis. In addition, due to their unique properties, ...

  • Amination

    Amination

    Biomedical Sciences Shirley (New York) March 11, 2019 Check with publisher

    Amination is the reaction process of introducing amine groups (-NH2) into organic molecules to form amines. Amines as a very potent drug functional group exist in most drug structures. For example, cyclized amines are considered to be the pharmacopho...