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  • Pracinostat (SB939)

    Pracinostat (SB939)

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 3-​[2-​butyl-​1-​[2-​(diethylamino)ethyl]-​1H-​benzimidazol-​5-​yl]-​N-​hydroxy-​2E-​propenamide; Pracinostat Description: Potent and oral inhibitor of histone deacetylase (HDAC), selective for class I, II and IV HDACs. SB 939 demonstrates ...

  • Salermide

    Salermide

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Abbr: Salermide(SIRT1, SIRT2) Synonyms: N-​[3-​[[(2-​hydroxy-​1-​naphthalenyl)methylene]amino]phenyl]-​a-​methyl-​benzeneacetamide Description: Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitor...

  • Vorinostat (SAHA)

    Vorinostat (SAHA)

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: Vorinostat; Suberanilohydroxamic Acid; MK-0683 Description: Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Prevents diabetes in a mouse model by immunoregulation and β-cell pretection. Cell permeable. Appearanc...

  • Ryuvidine

    Ryuvidine

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Description: Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton ...

  • Ruxolitinib, Free base

    Ruxolitinib, Free base

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: INCB018424; INC18424; NCB018424; NCB18424 Description: Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibros...

  • RSC133

    RSC133

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide Description: RSC-133 is an epigenetic modulator that effectively improves reprogramming of human somatic cells to pluripotent stem cells. Apparently, RSC-133 facilitates the re...

  • Ro 31-8220 methanesulfonate

    Ro 31-8220 methanesulfonate

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin Description: Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However,...

  • Ro 31-8220 methanesulfonate

    Ro 31-8220 methanesulfonate

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX Description: Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isof...

  • RG 108

    RG 108

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: RG-108, N-Phthalyl-L-tryptophan; or (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid Product Overview: A DNA methyltransferase (DNMT) inhibitor Description: A DNA methyltransferase (DNMT) inhibitor. RG108 causes demethylatio...

  • Remodelin

    Remodelin

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    ynonyms: 4-​[2-​(2-​cyclopentylidenehydrazinyl)-​4-​thiazolyl]-​benzonitrile Description: Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells v...

  • Quercetin, Dihydrate

    Quercetin, Dihydrate

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 3,5,7,3',4'-Pentahydroxyflavone Description: A plant-derived flavanoid. Cell-permeable. Inhibits PIM1 kinase (IC₅₀ = 1.1 µM), PI 3-Kinase (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM). Also acts as an anti-tumor agent; induces apoptosi...

  • Quercetin, Dihydrate

    Quercetin, Dihydrate

    Reagents - Supplies Shirley (New York) November 27, 2020 Check with publisher

    Synonyms: 3,5,7,3',4'-Pentahydroxyflavone Description: A plant-derived flavanoid. Cell-permeable. Inhibits PIM1 kinase (IC₅₀ = 1.1 µM), PI 3-Kinase (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM). Also acts as an anti-tumor agent; induces apoptosi...

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