Drug Development

Listings
  • Physicochemical Prediction

    Physicochemical Prediction

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Physicochemical properties are key factors in quantitative structure–property relationship (QSPR) studies in controlling the interactions between xenobiotics and living organisms. Computational approaches for toxicity prediction therefore generally r...

  • Quantitative structure–activity relationship (QSAR)

    Quantitative structure–activity relationship (QSAR)

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Quantitative structure–activity relationship (QSAR) is a method to build computational models, which attempts to find a significant correlation in statistics between structure and function. In drug design, structure refers to the molecular property o...

  • Activity Prediction

    Activity Prediction

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    In drug discovery, researchers are not only interested in detecting active molecules, but also in determining the biological activity observed in a particular molecule. At the same time, it is useful to identify the most representative subset of mole...

  • Lead Optimization

    Lead Optimization

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Lead optimization is a diversified operation in drug discovery, in which the chemical structures of compounds or biologics are modified to improve target’s specificity, selectivity, pharmacodynamics, pharmacokinetic and toxicological properties to ge...

  • Hit to Lead

    Hit to Lead

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Hit to Lead also known as lead generation is a prerequisite for the construction of new drugs’ molecular structures and the key first step in the development of new drugs. This stage aims to obtain each hit series and try to produce more potent and s...

  • Hit Identification

    Hit Identification

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    The entry point for chemistry program within drug discovery research is generally the identification of molecules of high specificity with an adequate activity in a suitable target assay. Such initial hits can be generated in a number of ways. It is ...

  • High-throughput screening

    High-throughput screening

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    High-throughput screening (HTS) is the process by which large numbers of compounds can be tested, in an automated fashion, for activity as inhibitors (antagonists) or activators (agonists) of a particular biological target, such as a cell-surface rec...

  • Library Design

    Library Design

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    A well-designed compound library contains a broad range of truly stored chemicals and/or virtual compounds, which can meet majority requirements and truly jump-start the search for new drugs. In addition, such compound library or chemical library is ...

  • custom libraries

    custom libraries

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Chemical libraries contain a collection of diversity of real or virtual chemical compounds, which offers customers a powerful guarantee for custom synthesis. These custom libraries utilize an advanced, chemistry-focused proprietary technology platfor...

  • Activity-based Libraries

    Activity-based Libraries

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    In general, screening libraries contain amounts of compounds for the demands of academia and industry, which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification...

  • Fragment Libraries

    Fragment Libraries

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Fragment-based drug discovery, also known as fragment-based lead discovery, is gaining momentum as a complementary approach to traditional screening. This is because significantly fewer compounds are required to be synthesized and screened by fragmen...

  • Medicinal chemistry

    Medicinal chemistry

    Drug Development Shirley (New York) January 10, 2019 Check with publisher

    Medicinal chemistry is an integrated discipline which links many scientific fields in researching and developing new drugs. Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherent...