A New Biomarker for Targeting Polysialic Acid

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  • Published date: October 22, 2022
    • United States
A New Biomarker for Targeting Polysialic Acid
A New Biomarker for Targeting Polysialic Acid

Some information-rich sugar molecules modify the surface of normal cells, and the particular information carried by glycoproteins and glycolipids is transmitted to cells to regulate the physiological processes of cells. Polysialic acid is one of the carbohydrates that specifically bind to receptor proteins by cell surface carbohydrate complexes. Polysialic acid (PSA) is a unique class of linear, homogeneous poly α2,8-linked sialic acid compounds, which are mainly attached to neural adhesion molecules in the vertebrate nervous system through typical N-linked glycosidic bonds. Because polysialic acid has a large number of negative charges and is hydrophilic, it will form a larger hydration radius. Therefore, NCAM bound to polysia will increase the distance between cell membranes when interacting with polysia, causing the distance between adjacent cells to be too large to lose adhesion, thus affecting the interaction between cell membranes. Because of this property, polysialic acid plays a crucial role in neural development by altering the adhesion of neural adhesion molecules in the nervous system to regulate neural cell development, neural guidance, and synapse formation.
https://www.profacgen.com/platform/drug-discovery/biosimilar-testing-services/a-new-biomarker-for-targeting-polysialic-acid

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Anna Camp
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