A New method for Self-Amplifying RNA Vaccines Delivery with Plant VLP

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  • Published date: October 22, 2022
    • United States
A New method for Self-Amplifying RNA Vaccines Delivery with Plant VLP
A New method for Self-Amplifying RNA Vaccines Delivery with Plant VLP

As one of the leading technologies in the research and development of the 2019-nCoV vaccine, mRNA vaccines have the advantages of low cost, high production efficiency, and high safety, and have great application potential for new infectious viruses that traditional vaccines cannot cope with. By delivering mRNA encoding viral antigens, mRNA vaccines express antigens in the body, stimulate the body's immune response, and play a role in preventing or treating diseases. mRNA can meet the needs of gene therapy, cancer therapy, and vaccines and is a very potent drug candidate. mRNA works by expressing proteins that stimulate the immune system to respond or treat. Therefore, the expression level of the protein is closely related to the efficacy of the therapy. A drawback of traditional mRNAs is that they are not very stable and are degraded within a few days within the cell, resulting in unsustainable protein expression levels. If it is used as a long-term treatment for the disease, it may require multiple and large injections of mRNA, which may increase the toxic and side effects of mRNA therapy. In addition, mRNA has high natural immunogenicity, and the in vivo delivery efficiency is low, making it difficult to play its role efficiently. Therefore, to realize the widespread application of mRNA vaccines, it is necessary to focus on solving protein expression problems and vaccine delivery.
https://www.profacgen.com/platform/drug-discovery/biosimilar-testing-services/a-new-method-for-self-amplifying-rna-vaccines-delivery-with-plant-vlp

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Anna Camp
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